منابع مشابه
Dietary n-3 and n-6 fatty acids alter avian metabolism: metabolism and abdominal fat deposition.
The effects of dietary saturated fatty acids and polyunsaturated fatty acids (PUFA) of the n-3 and n-6 series on weight gain, body composition and substrate oxidation were investigated in broiler chickens. At 3 weeks of age three groups of chickens (n 30; ten birds per group) were fed the fat-enriched experimental diets for 5 weeks. These diets were isonitrogenous, isoenergetic and contained 20...
متن کاملAcute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids.
RATIONALE Acute lung injury (ALI) remains an important cause of mortality in intensive care units. Inflammation is controlled by cytokines and eicosanoids derived from the n-6 fatty acid (FA) arachidonic acid (AA). The n-3 FA eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and mediators derived from EPA and DHA possess reduced inflammatory potency. OBJECTIVES To determine whether t...
متن کاملN-3 Polyunsaturated Fatty Acids, Body Fat and Inflammation
BACKGROUND Based on animal studies, n-3 polyunsaturated fatty acids (PUFAs) have been suggested to lower the risk of obesity and inflammation. We aimed to investigate if, among humans, intake of n-3 PUFAs was associated with i) total body fat, ii) body fat distribution and iii) obesity-related inflammatory markers. METHODS The study population consisted of 1,212 healthy individuals with infor...
متن کاملTotal fat and (n-3):(n-6) fat ratios influence eicosanoid production in mice.
Previous studies have not addressed the effect of differing fat intake on the effectiveness of varying (n-3) polyunsaturated fatty acid (PUFA) ingestion in altering tissue composition and eicosanoid production. This study examined (n-3):(n-6) PUFA ratios of 0, 0.1:1, 0.2:1, 0.4:1, and 1:1 with total fat at 5, 10, 15, and 20 g/100 g of diet and (n-6) PUFA fixed at 1.5 g/100 g of diet on tissue c...
متن کاملVery long chain n-3 and n-6 polyunsaturated fatty acids bind strongly to liver fatty acid-binding protein.
Synthesis of n-3 and n-6 very long chain-PUFAs (VLC-PUFAs) from 18-carbon essential fatty acids is differentially regulated. The predominant product arising from n-3 fatty acids is docosahexaenoic acid (22:6n-3), with the liver serving as the main site of production. The synthetic pathway requires movement of a 24-carbon intermediate from the endoplasmic reticulum to peroxisomes for retroconver...
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ژورنال
عنوان ژورنال: Nature
سال: 2004
ISSN: 0028-0836,1476-4687
DOI: 10.1038/427504a